Archive for the natural science Category

Hwang Woo-suk is Guilty!

Posted in hwang woo-suk with tags , , , on October 26, 2009 by arcticpenguin

After three years and 43 hearings, the Korean court finally decided to put an end to the whole Hwang scandal. Hwang was sentenced to 2 years in prison but the sentence is suspended for 3 years. Basically what this means is that Hwang is supposed to go to jail for two years but that it’s being put off for three years; if Hwang does not violate the law during that time, the jail sentence is cleared and the guilty verdict no longer applies. In most cases with high-profile in Korea, a person who receives this kind of sentence will end up not going to jail.

*Bioethics law violation => GUILTY
*Fraud => NOT GUILTY (The Times Online says “guilty of fraud” which is incorrect)
*Embezzling funds => GUILTY

Despite the disgrace, Hwang isn’t in such a bad position (he seems pretty happy in all the press photos). He’s head of Sooam Biotech, a privately funded research center where he continues to do cloning work on animals instead of humans (good call: although he faked the human cloning research, he was proven to have cloned the world’s first dog). Since then, he’s been cloning dogs for commercial purposes and cloning mini pigs for human organ transplants.

A few months ago, he signed an MOU with Gyeonggi province to conduct joint research to clone gnotobiotic mini pigs that have diabetes so that they can test drugs on the pigs. (Apparently pigs are better subjects than rats.) He also has a bunch of devout followers (comprised of various religious groups, politicians…) who not only support him emotionally, but are willing to shell out their money for his research.

Blue-Green Algae Pollutes Charles River: Is Beautifying Boston’s Esplanade Endangering the Water?

Posted in natural science with tags , , , , , , , , on May 15, 2009 by arcticpenguin

[NOTE: Dug this up in my archives...was written in 2007 but not published anywhere.]

“I love that dirty water. Oh oh Boston you’re my home.”

The hit 1960s Standells song “Dirty Water” is a pseudo anthem sung on nights of victory at Fenway Park, made famous more recently by the punk band Dropkick Murphys. But fans of the Red Sox may croon that they love the dirty water without realizing that baseball may be one of the factors that actually contaminates the Charles River.

Because of its long-time pollution, the U.S. Environmental Protection Agency and local governments have been working to clean up the Charles River. Millions of dollars have been spent over the past 12 years to clean up much of the sewage and industrial waste. Since 1995, the EPA has moved up the rating on the river’s quality from a D to B-plus last summer, although it is still not fit for swimming. “We’ve made huge progress cleaning up the Charles, especially in terms of removing sewage and other sources of bacteria, but for the past two summers, toxic algae blooms have raised concerns about public safety,” said Robert Zimmerman, executive director of the Charles River Watershed Association.

Organizations, however, are overlooking the fact that some of their beautification projects are polluting the river on a different level. Fertilizers and fungicides applied to Teddy Ebersol’s Red Sox Fields may be encouraging yet another danger: blue-green algae. Blue-green algae, or cyanobacteria, thrive in warm water that is rich in nutrients. When they die, the algae create a toxin that can cause skin rashes or other irritation. Ingestion of the toxin can lead to serious liver and nervous system damage.

Civic environmental protection groups such as Friends of the White Geese are claiming that fungicides and use of fertilizers on Ebersol Fields were what caused the algal bloom.

Fungus Problems at Ebersol Fields

Ebersol Fields was named after Teddy Ebersol, a young Red Sox fan who died in a plane crash. The park consists of two baseball/ softball diamonds, youth soccer fields, and a regulation-sized soccer field. It was a 1.8 million dollar renewal project, re-opening to the public in 2006 and part of the master plan in beautifying the Esplanade. Unlike other grass areas, it is equipped with commercial sod, which requires regular fertilizer treatment.

In July 2006, Ebersol Fields developed a fungus and was treated with a chemical fungicide called Tartan. Made by Bayer, Tartan is a preventive and curative fungicide that may be applied to turf sites such as golf courses, institutional and commercial lawns, sports fields, and parks.

According to the label on Tartan, the pesticide is toxic to fish and aquatic invertebrates, and should not be applied directly to water or to areas near water. “Drift and runoff may be hazardous to aquatic organisms in neighboring areas. Do not make applications when weather conditions favor drift from target area. It is a violation of Federal law to use this product in a manner inconsistent with its labeling,” the warning reads.

“Despite the explicitly-stated hazards, Tartan it was applied two times to Ebersol Fields—on Aug. 10 and Sept. 1,” said Robert Tremouille, head of Friends of the White Geese. “The two treatments were made with supplementary field fertilization and irrigation by the Massachusetts Department of Conservation and Recreation.”

Is Fungicide Creating Algae?

Perhaps coincidentally, the algae bloom exploded after the first application of Tartan. The algal level dropped towards the end of August, but then went up in September, after the second Tartan application. It turned the lagoons and river to an eerie shade of glowing pea-green and cancelled the Charles River Swim—a racing event that was supposed to commemorate improving conditions of the water.

The fungicide application to Ebersol Fields has not been proven to be the direct cause of the algae bloom. “No one knows whether or not there is a link between the use of Tartan and the algae bloom,” Representative Martha M. Waltz of the State House said.

Some, however, feel that the government should shoulder some of the responsibility. “The Department of Conservation argues that the fertilizers are organic, but even organic fertilizers contain certain amounts of phosphorus,” said 64-year old activist Marilyn Wellons.

According to the U.S. Environmental Protection Agency, phosphorus was responsible for the explosive algae growth in the Charles River during the past two summers. Phosphorus gets into the river from various sources: storm water runoff from streets, buildings and parking lots, fertilized lawns, and wastewater treatment plant discharges. Authorities, however, are all pointing fingers away from themselves due to lack of scientific evidence on which one of those factors caused the most phosphorus. The Charles River Watershed Association is blaming highways and factories—working closely with the Conservation Law Foundation to force state agencies and private companies to clean up their discharges. The association filed lawsuits against the Massachusetts Highway Department to clean up polluted highway runoff and challenged the Mirant Kendall—a factory that uses river water to cool its engines—to lower the amount of hot water that its plant discharges into the river.

While hot water being poured into the river is certainly not helpful, records from Mirant Kendall show that it is unlikely that the factory is mainly responsible for the algae bloom. The level of hot water discharge during the past couple years has been going down in the past two years, whereas the level of algae has been going up.

Though unsure of the cause, officials do know that they must come up with realistic solutions to prevent further algae blooms. A study that the environmental protection agency released in October showed that current phosphorus levels in the Charles are 117 percent above levels allowed by the Clean Water Act. A few months ago, the agency and the Massachusetts Department of Environmental Protection issued a new target to reduce the amount of nutrient phosphorus entering the river.

Korea allows research on human embryos, but Hwang Woo-suk doesn’t get to do it

Posted in hwang woo-suk with tags , , , on April 29, 2009 by arcticpenguin

Spurred by the Obama administration’s lift on a previous ban on human embryonic stem cell research in the United State, South Korea is also lifting its ban, the JoongAng Daily. and AP report. Not everyone gets to do the research, though. The lucky research institute is the CHA Medical Center, which has the largest private stem cell research lab in Korea. Hwang Woo-suk, who was the only scientist allowed to do research on human embryos before he was stripped of his license a few years ago, will not be allowed to resume his research. Hwang currently does animal cloning research at a private lab that he founded after he was dismissed from his professorship at Seoul National University.

Korea’s decision to allow research on the cloning of human stem cells was not surprising, especially amidst a lot of public discussion about re-opening research in the United States. Koreans have a very sentimental attachment to the study of embryonic human stem cell cloning that goes back to the days before Hwang was discovered to have faked his research. The story of Hwang Woo-suk’s spectacular rise (and equally spectacular fall) is unique in terms of the role Korean nationalism played in it. It occurred at a time when Korea was seeking a new economic business model and the United States had banned research on human embryos, giving Korea an opening to become a world leader. And while previous science frauds were usually detected and played out largely within the science community, the Hwang case was different in that the Korean media not only made Hwang a celebrity even before his work was published in a major scientific paper, but it also conducted the in-depth investigation that led to his demise.

Now, however, it doesn’t look like Hwang will be playing a role in any future human stem cell research. For the meantime, anyway.

RNL Claims Stem Cell Treatment Relieved Arthritis

Posted in hwang woo-suk, natural science with tags , on April 6, 2009 by arcticpenguin

A press release from RNL BIO claims that their stem cell treatment helped an American artist with a severe case of arthritis. I would be skeptical, but I’ve seen dogs benefiting from this treatment, so maybe it works in some cases. Who knows? Still, it seems awfully fast that they came up with this treatment because it was just last January that RNL announced that they had cloned puppies using the nucleus from stem cells derived from fat tissues. Apparently they have been using this stem-cell-from-fat technique for a number of different things…?

One must note that one of the guys behind RNL is Lee Byeong-cheon, who does a lot of dog cloning at Seoul National University. He and Hwang Woo-suk used to work in the same lab, but Hwang was fired and now has his own enterprise going. I’m not quite sure who is in charge of the adult stem cell research at RNL; maybe I should ask.

Here is the press release:

John Lawson Cullison, Jr., an artist known for his work in the genre of visionary realism or “new age art,” lost his ability to paint due to the effects of arthritis. This incurable condition is due to the degeneration in cartilage tissue and symptoms include: pain, tenderness in the joints, stiffness, loss of flexibility, bone spurs and severe swelling. Pain management and joint replacement surgery are the typical means to treating this condition. Cullison was taking prescription pain medication for over 15 years when he finally decided to seek treatment that was unavailable in the United States.

RNL Bio, a South Korean adult stem cell therapy company, developed a method to take one’s own stem cells from fat tissue and make identical copies that have no genetic modifications and no cancer risks so that high doses of stem cells can be administered back into the body. The stem cells that come from fat tissue can easily form new tissues. Given that characteristic, the stem cells have the capacity to treat any tissue degenerative disease which includes, Parkinson’s Disease, Spinal Cord Injury, Renal Failure, among many. When Cullison heard of the treatment, he sent a small fat sample to RNL Bio, where the cells would be manufactured under the strictest safety and quality conditions.

February 2009, Cullison made the trip to Seoul, South Korea where he was escorted by RNL staff to The Sunrise Regenerative Medical Center, their stem cell hospital in Yanji, China to receive intravenous and local injections of his own stem cells. When asked about his decision to seek this new and developing treatment, he said, “I had more faith in that [the fact that RNL was using my own stem cells] because I knew that I would be receiving the material that genetically was supposed to be in me.”.

A week after his injection, Cullison began to see small improvements and after two weeks, he no longer needed his cane to walk. He noticed that his joints were feeling better, his vision was improving to the point that his glasses were outdated, his eyes were getting bluer (eye pigmentation is often an indicator of good health) and his legs were getting stronger. “This is major improvement and it’s only been 2 weeks! Six months from now, I’ll be doing back-flips!” Only three weeks post treatment, Cullison reported that he was no longer taking any medication and back to painting his pictures.

President and CEO of RNL Bio, Dr. Jeong Chan Ra said, “John Cullison arrived in Korea as an old man. He is returning to his home, an adolescent”. After witnessing the remarkable improvement of Cullison as well as patients being treated with RNL stem cells, Ra is committed to making RNL stem cell therapy an accessible and affordable treatment, globally.